What OFX is
OFX is the format behind the Download Transactions button on your bank's website. Version 1 is SGML, where a leaf element has an opening tag and no closing one. Version 2 is real XML. QFX is Intuit's variant of the same thing with a few extra tags, which is why a .qfx file opens in Quicken and is refused by software that only knows plain OFX.
Retail banks, credit card issuers and brokerages, because it is what Quicken and Microsoft Money asked for and the industry standardised on.
What Excel is
An Excel workbook is a zip archive of XML parts describing sheets, cells, formulas, styles and charts. The .xlsx extension is that format; .xls is the older binary one from before 2007.
Finance, operations and anyone who received a file from finance or operations.
What changes when you convert OFX to Excel
Each STMTTRN block becomes a row: date, amount, type, payee, memo, cheque number and the bank's own transaction id. The account number and currency come from the statement header and are added to every row, so a file merged with another still says which account it came from. Both the SGML and the XML flavour are read the same way.
You get a single sheet with a header row and column widths sized to the content. Values are written as text unless type inference is on, which keeps identifiers like 0044 or 007 intact.
What carries over from OFX to Excel
One property of the OFX has no home in Excel, and it is worth knowing which before you convert.
OFX can hold a value that is itself a list or an object. Excel has only flat cells, so nested values are flattened into one cell rather than being spread across columns.
Both formats record types, so numbers, booleans and nulls survive as themselves rather than as text.